COVID-19 – Considerations for the paediatric rheumatologist
Identifieur interne : 000914 ( 2020/Analysis ); précédent : 000913; suivant : 000915COVID-19 – Considerations for the paediatric rheumatologist
Auteurs : Christian M. Hedrich [Royaume-Uni]Source :
- Clinical Immunology (Orlando, Fla.) [ 1521-6616 ] ; 2020.
Abstract
The novel coronavirus SARS-CoV2 is a threat to the health and well-being of millions of lifes across the globe. A significant proportion of adult patients require hospitalisation and may develop severe life-threatening complications. Children, on the other hand, can carry and transmit the virus, but usually do not develop severe disease. Mortality in the paediatric age-group is relatively low. Differences in virus containment and clearance, as well as reduced inflammation-related tissue and organ damage may be caused by age-specific environmental and host factors. Since severe complications in adults are frequently caused by uncontrolled immune responses and a resulting “cytokine storm” that may be controlled by targeted blockade of cytokines, previously established treatment with immunosuppressive treatments may indeed protect children from complications.
Url:
DOI: 10.1016/j.clim.2020.108420
PubMed: 32283324
PubMed Central: 7151358
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001717
- to stream Pmc, to step Curation: 001717
- to stream Pmc, to step Checkpoint: 000362
- to stream PubMed, to step Corpus: 000190
- to stream PubMed, to step Curation: 000190
- to stream PubMed, to step Checkpoint: 000759
- to stream Ncbi, to step Merge: 003935
- to stream Ncbi, to step Curation: 003935
- to stream Ncbi, to step Checkpoint: 003935
- to stream Main, to step Merge: 000914
- to stream Main, to step Curation: 000914
- to stream Main, to step Exploration: 000914
- to stream 2020, to step Extraction: 000914
Links to Exploration step
PMC:7151358Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">COVID-19 – Considerations for the paediatric rheumatologist</title><author><name sortKey="Hedrich, Christian M" sort="Hedrich, Christian M" uniqKey="Hedrich C" first="Christian M." last="Hedrich">Christian M. Hedrich</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Women's & Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Women's & Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af0010">Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32283324</idno><idno type="pmc">7151358</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151358</idno><idno type="RBID">PMC:7151358</idno><idno type="doi">10.1016/j.clim.2020.108420</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">001717</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001717</idno><idno type="wicri:Area/Pmc/Curation">001717</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001717</idno><idno type="wicri:Area/Pmc/Checkpoint">000362</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000362</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:32283324</idno><idno type="wicri:Area/PubMed/Corpus">000190</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000190</idno><idno type="wicri:Area/PubMed/Curation">000190</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000190</idno><idno type="wicri:Area/PubMed/Checkpoint">000759</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000759</idno><idno type="wicri:Area/Ncbi/Merge">003935</idno><idno type="wicri:Area/Ncbi/Curation">003935</idno><idno type="wicri:Area/Ncbi/Checkpoint">003935</idno><idno type="wicri:doubleKey">1521-6616:2020:Hedrich C:covid:considerations:for</idno><idno type="wicri:Area/Main/Merge">000914</idno><idno type="wicri:Area/Main/Curation">000914</idno><idno type="wicri:Area/Main/Exploration">000914</idno><idno type="wicri:Area/2020/Extraction">000914</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">COVID-19 – Considerations for the paediatric rheumatologist</title><author><name sortKey="Hedrich, Christian M" sort="Hedrich, Christian M" uniqKey="Hedrich C" first="Christian M." last="Hedrich">Christian M. Hedrich</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Women's & Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Women's & Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af0010">Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author></analytic><series><title level="j">Clinical Immunology (Orlando, Fla.)</title><idno type="ISSN">1521-6616</idno><idno type="eISSN">1521-7035</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The novel coronavirus SARS-CoV2 is a threat to the health and well-being of millions of lifes across the globe. A significant proportion of adult patients require hospitalisation and may develop severe life-threatening complications. Children, on the other hand, can carry and transmit the virus, but usually do not develop severe disease. Mortality in the paediatric age-group is relatively low. Differences in virus containment and clearance, as well as reduced inflammation-related tissue and organ damage may be caused by age-specific environmental and host factors. Since severe complications in adults are frequently caused by uncontrolled immune responses and a resulting “cytokine storm” that may be controlled by targeted blockade of cytokines, previously established treatment with immunosuppressive treatments may indeed protect children from complications.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zhu, N" uniqKey="Zhu N">N. Zhu</name></author><author><name sortKey="Zhang, D" uniqKey="Zhang D">D. Zhang</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Henry, B M" uniqKey="Henry B">B.M. Henry</name></author><author><name sortKey="Lippi, G" uniqKey="Lippi G">G. Lippi</name></author><author><name sortKey="Plebani, M" uniqKey="Plebani M">M. Plebani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dong, Y" uniqKey="Dong Y">Y. Dong</name></author><author><name sortKey="Mo, X" uniqKey="Mo X">X. Mo</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y. Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamming, I" uniqKey="Hamming I">I. Hamming</name></author><author><name sortKey="Timens, W" uniqKey="Timens W">W. Timens</name></author><author><name sortKey="Bulthuis, M L" uniqKey="Bulthuis M">M.L. Bulthuis</name></author><author><name sortKey="Lely, A T" uniqKey="Lely A">A.T. Lely</name></author><author><name sortKey="Navis, G" uniqKey="Navis G">G. Navis</name></author><author><name sortKey="Van Goor, H" uniqKey="Van Goor H">H. van Goor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name></author><author><name sortKey="Dandekar, A A" uniqKey="Dandekar A">A.A. Dandekar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prompetchara, E" uniqKey="Prompetchara E">E. Prompetchara</name></author><author><name sortKey="Ketloy, C" uniqKey="Ketloy C">C. Ketloy</name></author><author><name sortKey="Palaga, T" uniqKey="Palaga T">T. Palaga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E. de Wit</name></author><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N. van Doremalen</name></author><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D. Falzarano</name></author><author><name sortKey="Munster, V J" uniqKey="Munster V">V.J. Munster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kindler, E" uniqKey="Kindler E">E. Kindler</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V. Thiel</name></author><author><name sortKey="Weber, F" uniqKey="Weber F">F. Weber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, R" uniqKey="Lu R">R. Lu</name></author><author><name sortKey="Zhao, X" uniqKey="Zhao X">X. Zhao</name></author><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, C" uniqKey="Huang C">C. Huang</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Atkin Smith, G K" uniqKey="Atkin Smith G">G.K. Atkin-Smith</name></author><author><name sortKey="Duan, M" uniqKey="Duan M">M. Duan</name></author><author><name sortKey="Chen, W" uniqKey="Chen W">W. Chen</name></author><author><name sortKey="Poon, I K H" uniqKey="Poon I">I.K.H. Poon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, W" uniqKey="Zhang W">W. Zhang</name></author><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y. Zhao</name></author><author><name sortKey="Zhang, F" uniqKey="Zhang F">F. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fu, Y" uniqKey="Fu Y">Y. Fu</name></author><author><name sortKey="Cheng, Y" uniqKey="Cheng Y">Y. Cheng</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y. Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takada, A" uniqKey="Takada A">A. Takada</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y. Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, Y" uniqKey="Jin Y">Y. Jin</name></author><author><name sortKey="Yang, H" uniqKey="Yang H">H. Yang</name></author><author><name sortKey="Ji, W" uniqKey="Ji W">W. Ji</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simon, A K" uniqKey="Simon A">A.K. Simon</name></author><author><name sortKey="Hollander, G A" uniqKey="Hollander G">G.A. Hollander</name></author><author><name sortKey="Mcmichael, A" uniqKey="Mcmichael A">A. McMichael</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uhlen, M" uniqKey="Uhlen M">M. Uhlen</name></author><author><name sortKey="Karlsson, M J" uniqKey="Karlsson M">M.J. Karlsson</name></author><author><name sortKey="Zhong, W" uniqKey="Zhong W">W. Zhong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imai, Y" uniqKey="Imai Y">Y. Imai</name></author><author><name sortKey="Kuba, K" uniqKey="Kuba K">K. Kuba</name></author><author><name sortKey="Rao, S" uniqKey="Rao S">S. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="D Antiga, L" uniqKey="D Antiga L">L. D'Antiga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, D" uniqKey="Sun D">D. Sun</name></author><author><name sortKey="Li, H" uniqKey="Li H">H. Li</name></author><author><name sortKey="Lu, X X" uniqKey="Lu X">X.X. Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Guo, F" uniqKey="Guo F">F. Guo</name></author><author><name sortKey="Cao, Y" uniqKey="Cao Y">Y. Cao</name></author><author><name sortKey="Li, L" uniqKey="Li L">L. Li</name></author><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y. Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Su, L" uniqKey="Su L">L. Su</name></author><author><name sortKey="Ma, X" uniqKey="Ma X">X. Ma</name></author><author><name sortKey="Yu, H" uniqKey="Yu H">H. Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qiu, H" uniqKey="Qiu H">H. Qiu</name></author><author><name sortKey="Wu, J" uniqKey="Wu J">J. Wu</name></author><author><name sortKey="Hong, L" uniqKey="Hong L">L. Hong</name></author><author><name sortKey="Luo, Y" uniqKey="Luo Y">Y. Luo</name></author><author><name sortKey="Song, Q" uniqKey="Song Q">Q. Song</name></author><author><name sortKey="Chen, D" uniqKey="Chen D">D. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, J" uniqKey="Lin J">J. Lin</name></author><author><name sortKey="Duan, J" uniqKey="Duan J">J. Duan</name></author><author><name sortKey="Tan, T" uniqKey="Tan T">T. Tan</name></author><author><name sortKey="Fu, Z" uniqKey="Fu Z">Z. Fu</name></author><author><name sortKey="Dai, J" uniqKey="Dai J">J. Dai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, F" uniqKey="Zheng F">F. Zheng</name></author><author><name sortKey="Liao, C" uniqKey="Liao C">C. Liao</name></author><author><name sortKey="Fan, Q H" uniqKey="Fan Q">Q.H. Fan</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Hedrich, Christian M" sort="Hedrich, Christian M" uniqKey="Hedrich C" first="Christian M." last="Hedrich">Christian M. Hedrich</name></noRegion><name sortKey="Hedrich, Christian M" sort="Hedrich, Christian M" uniqKey="Hedrich C" first="Christian M." last="Hedrich">Christian M. Hedrich</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/2020/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000914 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/2020/Analysis/biblio.hfd -nk 000914 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= 2020
|étape= Analysis
|type= RBID
|clé= PMC:7151358
|texte= COVID-19 – Considerations for the paediatric rheumatologist
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/2020/Analysis/RBID.i -Sk "pubmed:32283324" \
| HfdSelect -Kh $EXPLOR_AREA/Data/2020/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |